Computational Biomechanics for Medicine by Unknown

Author:Unknown
Language: eng
Format: epub
ISBN: 9783030159238
Publisher: Springer International Publishing

4 Conclusion

This paper discusses MRI-based strain measurement calibration for studying brain motion during head impact. The study contributes the design of a quantitative phantom for evaluation against high-speed video, new data for evaluation of motion estimation methodology, and a description of calibration considering the imaging acquisition process. We show that excitation delay, segmented acquisition, and strain reference alter displacement and strain results, but resolution matching and informed interpretation of results enables adequate comparison across modalities. In summary, the comparison process should include: (1) spatiotemporal registration between domains, (2) filtering the source of strain to match resolutions, and (3) a consistent strain reference. Future research includes measurement optimization and evaluation of 3D data. Calibration images are available at iacl.​jhu.​edu/​impactdata.

Acknowledgments

This research was funded by NIH Grants R01-NS055951 and R01-DC014717, and support by the U.S. Department of Defense in the Center for Neuroscience and Regenerative Medicine.

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